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Cells 2012, 1(4), 851-873; doi:10.3390/cells1040851
Review

Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration

1,* , 1,2
 and 1
Received: 3 September 2012; in revised form: 29 September 2012 / Accepted: 10 October 2012 / Published: 18 October 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
View Full-Text   |   Download PDF [218 KB, uploaded 18 October 2012]
Abstract: Retinal degenerative diseases constitute a major cause of irreversible blindness in the world. Stem cell-based therapies offer hope for these patients at risk of or suffering from blindness due to the deterioration of the neural retina. Various sources of stem cells are currently being investigated, ranging from human embryonic stem cells to adult-derived induced pluripotent stem cells as well as human Müller stem cells, with the first clinical trials to investigate the safety and tolerability of human embryonic stem cell-derived retinal pigment epithelium cells having recently commenced. This review aims to summarize the latest advances in the development of stem cell strategies for the replacement of retinal neurons and their supportive cells, the retinal pigment epithelium (RPE) affected by retinal degenerative conditions. Particular emphasis will be given to the advances in stem cell transplantation and the challenges associated with their translation into clinical practice.
Keywords: stem cells; retina; retinal pigment epithelium; photoreceptors; retinal ganglion cells; retinal degenerative diseases; transplantation; translational research stem cells; retina; retinal pigment epithelium; photoreceptors; retinal ganglion cells; retinal degenerative diseases; transplantation; translational research
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Becker, S.; Jayaram, H.; Limb, G.A. Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration. Cells 2012, 1, 851-873.

AMA Style

Becker S, Jayaram H, Limb GA. Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration. Cells. 2012; 1(4):851-873.

Chicago/Turabian Style

Becker, Silke; Jayaram, Hari; Limb, G. Astrid. 2012. "Recent Advances towards the Clinical Application of Stem Cells for Retinal Regeneration." Cells 1, no. 4: 851-873.



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