Cells 2012, 1(4), 874-885; doi:10.3390/cells1040874
Review

The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues

1 Department of Medicine, St. Luke’s Roosevelt Health Sciences Center, Antenucci Building, 432 West 58th Street, Room 311, New York, NY 10019, USA 2 Department of Medicine, Vanderbilt University, 1161 21st. Ave S, T1218 MCN, Nashville, TN 37232, USA
* Author to whom correspondence should be addressed.
Received: 28 August 2012; in revised form: 19 September 2012 / Accepted: 25 September 2012 / Published: 19 October 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
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Abstract: Tissue resident mesenchymal stem cells (MSCs) are important regulators of tissue repair or regeneration, fibrosis, inflammation, angiogenesis and tumor formation. Bone marrow derived mesenchymal stem cells (BM-MSCs) and endothelial progenitor cells (EPC) are currently being considered and tested in clinical trials as a potential therapy in patients with such inflammatory lung diseases including, but not limited to, chronic lung disease, pulmonary arterial hypertension (PAH), pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD)/emphysema and asthma. However, our current understanding of tissue resident lung MSCs remains limited. This review addresses how environmental cues impact on the phenotype and function of this endogenous stem cell pool. In addition, it examines how these local factors influence the efficacy of cell-based treatments for lung diseases.
Keywords: mesenchymal stem cell; lung disease; hypertension; fibrosis; pulmonary regeneration; PDGF-BB; Wnt; sfrp

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MDPI and ACS Style

Foronjy, R.F.; Majka, S.M. The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues. Cells 2012, 1, 874-885.

AMA Style

Foronjy RF, Majka SM. The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues. Cells. 2012; 1(4):874-885.

Chicago/Turabian Style

Foronjy, Robert F.; Majka, Susan M. 2012. "The Potential for Resident Lung Mesenchymal Stem Cells to Promote Functional Tissue Regeneration: Understanding Microenvironmental Cues." Cells 1, no. 4: 874-885.

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