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Neovascularization in Tissue Engineering
Division of Cardiac Surgery, McGill University Health Center, McGill University, 687 Pine Avenue West, Suite S8.73b, Montreal H3A-1A1, Quebec, Canada
Division of Surgical Research, McGill University Health Center, McGill University, 687 Pine Avenue West, Suite S8.73b, Montreal H3A-1A1, Quebec, Canada
* Author to whom correspondence should be addressed.
Received: 31 August 2012; in revised form: 8 November 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
Abstract: A prerequisite for successful tissue engineering is adequate vascularization that would allow tissue engineering constructs to survive and grow. Angiogenic growth factors, alone and in combination, have been used to achieve this, and gene therapy has been used as a tool to enable sustained release of these angiogenic proteins. Cell-based therapy using endothelial cells and their precursors presents an alternative approach to tackling this challenge. These studies have occurred on a background of advancements in scaffold design and assays for assessing neovascularization. Finally, several studies have already attempted to translate research in neovascularization to clinical use in the blossoming field of therapeutic angiogenesis.
Keywords: neovascularization; angiogenesis; therapeutic angiogenesis; endothelial progenitor cells
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MDPI and ACS Style
Chung, J.C.-Y.; Shum-Tim, D. Neovascularization in Tissue Engineering. Cells 2012, 1, 1246-1260.
Chung JC-Y, Shum-Tim D. Neovascularization in Tissue Engineering. Cells. 2012; 1(4):1246-1260.
Chung, Jennifer C.-Y.; Shum-Tim, Dominique. 2012. "Neovascularization in Tissue Engineering." Cells 1, no. 4: 1246-1260.