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Cells 2012, 1(4), 1246-1260; doi:10.3390/cells1041246

Neovascularization in Tissue Engineering

Received: 31 August 2012 / Revised: 8 November 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
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A prerequisite for successful tissue engineering is adequate vascularization that would allow tissue engineering constructs to survive and grow. Angiogenic growth factors, alone and in combination, have been used to achieve this, and gene therapy has been used as a tool to enable sustained release of these angiogenic proteins. Cell-based therapy using endothelial cells and their precursors presents an alternative approach to tackling this challenge. These studies have occurred on a background of advancements in scaffold design and assays for assessing neovascularization. Finally, several studies have already attempted to translate research in neovascularization to clinical use in the blossoming field of therapeutic angiogenesis.
Keywords: neovascularization; angiogenesis; therapeutic angiogenesis; endothelial progenitor cells neovascularization; angiogenesis; therapeutic angiogenesis; endothelial progenitor cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chung, J.C.-Y.; Shum-Tim, D. Neovascularization in Tissue Engineering. Cells 2012, 1, 1246-1260.

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