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Signals and Cells Involved in Regulating Liver Regeneration
Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
* Author to whom correspondence should be addressed.
Received: 3 October 2012; in revised form: 27 November 2012 / Accepted: 7 December 2012 / Published: 13 December 2012
Abstract: Liver regeneration is a complex phenomenon aimed at maintaining a constant liver mass in the event of injury resulting in loss of hepatic parenchyma. Partial hepatectomy is followed by a series of events involving multiple signaling pathways controlled by mitogenic growth factors (HGF, EGF) and their receptors (MET and EGFR). In addition multiple cytokines and other signaling molecules contribute to the orchestration of a signal which drives hepatocytes into DNA synthesis. The other cell types of the liver receive and transmit to hepatocytes complex signals so that, in the end of the regenerative process, complete hepatic tissue is assembled and regeneration is terminated at the proper time and at the right liver size. If hepatocytes fail to participate in this process, the biliary compartment is mobilized to generate populations of progenitor cells which transdifferentiate into hepatocytes and restore liver size.
Keywords: liver regeneration; hepatocyte; hepatocyte growth factor; epidermal growth factor; partial hepatectomy; transdifferentitation; oval cell
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MDPI and ACS Style
Kang, L.-I.; Mars, W.M.; Michalopoulos, G.K. Signals and Cells Involved in Regulating Liver Regeneration. Cells 2012, 1, 1261-1292.
Kang L-I, Mars WM, Michalopoulos GK. Signals and Cells Involved in Regulating Liver Regeneration. Cells. 2012; 1(4):1261-1292.
Kang, Liang-I.; Mars, Wendy M.; Michalopoulos, George K. 2012. "Signals and Cells Involved in Regulating Liver Regeneration." Cells 1, no. 4: 1261-1292.