Cells 2012, 1(4), 1061-1088; doi:10.3390/cells1041061
Review

Mesenchymal Stem or Stromal Cells from Amnion and Umbilical Cord Tissue and Their Potential for Clinical Applications

1,2,†email, 3,†email, 3email, 2,4email, 2,4email, 1,2email, 1,2email and 3,* email
Received: 4 September 2012; in revised form: 29 October 2012 / Accepted: 5 November 2012 / Published: 12 November 2012
(This article belongs to the Special Issue Tissue and Organ Regeneration)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Mesenchymal stem or stromal cells (MSC) have proven to offer great promise for cell-based therapies and tissue engineering applications, as these cells are capable of extensive self-renewal and display a multilineage differentiation potential. Furthermore, MSC were shown to exhibit immunomodulatory properties and display supportive functions through parakrine effects. Besides bone marrow (BM), still today the most common source of MSC, these cells were found to be present in a variety of postnatal and extraembryonic tissues and organs as well as in a large variety of fetal tissues. Over the last decade, the human umbilical cord and human amnion have been found to be a rich and valuable source of MSC that is bio-equivalent to BM-MSC. Since these tissues are discarded after birth, the cells are easily accessible without ethical concerns.
Keywords: MSC; mesenchymal stem cell; mesenchymal stromal cell; amnion; umbilical cord; clinical applications
PDF Full-text Download PDF Full-Text [448 KB, uploaded 12 November 2012 09:29 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Lindenmair, A.; Hatlapatka, T.; Kollwig, G.; Hennerbichler, S.; Gabriel, C.; Wolbank, S.; Redl, H.; Kasper, C. Mesenchymal Stem or Stromal Cells from Amnion and Umbilical Cord Tissue and Their Potential for Clinical Applications. Cells 2012, 1, 1061-1088.

AMA Style

Lindenmair A, Hatlapatka T, Kollwig G, Hennerbichler S, Gabriel C, Wolbank S, Redl H, Kasper C. Mesenchymal Stem or Stromal Cells from Amnion and Umbilical Cord Tissue and Their Potential for Clinical Applications. Cells. 2012; 1(4):1061-1088.

Chicago/Turabian Style

Lindenmair, Andrea; Hatlapatka, Tim; Kollwig, Gregor; Hennerbichler, Simone; Gabriel, Christian; Wolbank, Susanne; Redl, Heinz; Kasper, Cornelia. 2012. "Mesenchymal Stem or Stromal Cells from Amnion and Umbilical Cord Tissue and Their Potential for Clinical Applications." Cells 1, no. 4: 1061-1088.

Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert