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Cells 2012, 1(3), 617-630; doi:10.3390/cells1030617

How Human Tumor Viruses Make Use of Autophagy

1
Department of Bacteriology and Food Research Institute, Microbial Sciences Building, University of Wisconsin-Madison, Madison, WI 53706, USA
2
Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
*
Author to whom correspondence should be addressed.
Received: 1 July 2012 / Revised: 11 August 2012 / Accepted: 21 August 2012 / Published: 27 August 2012
(This article belongs to the Special Issue Autophagy)
View Full-Text   |   Download PDF [299 KB, uploaded 27 August 2012]   |  

Abstract

Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway.
Keywords: Epstein-Barr Virus; Kaposi’s Sarcoma Herpesvirus; Hepatitis B Virus; Hepatitis C Virus; human tumor virus; autophagy; cancer Epstein-Barr Virus; Kaposi’s Sarcoma Herpesvirus; Hepatitis B Virus; Hepatitis C Virus; human tumor virus; autophagy; cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pratt, Z.L.; Sugden, B. How Human Tumor Viruses Make Use of Autophagy. Cells 2012, 1, 617-630.

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