Cells 2012, 1(3), 617-630; doi:10.3390/cells1030617

How Human Tumor Viruses Make Use of Autophagy

1email and 2,* email
Received: 1 July 2012; in revised form: 11 August 2012 / Accepted: 21 August 2012 / Published: 27 August 2012
(This article belongs to the Special Issue Autophagy)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway.
Keywords: Epstein-Barr Virus; Kaposi’s Sarcoma Herpesvirus; Hepatitis B Virus; Hepatitis C Virus; human tumor virus; autophagy; cancer
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MDPI and ACS Style

Pratt, Z.L.; Sugden, B. How Human Tumor Viruses Make Use of Autophagy. Cells 2012, 1, 617-630.

AMA Style

Pratt ZL, Sugden B. How Human Tumor Viruses Make Use of Autophagy. Cells. 2012; 1(3):617-630.

Chicago/Turabian Style

Pratt, Zachary L.; Sugden, Bill. 2012. "How Human Tumor Viruses Make Use of Autophagy." Cells 1, no. 3: 617-630.

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