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How Human Tumor Viruses Make Use of Autophagy
Department of Bacteriology and Food Research Institute, Microbial Sciences Building, University of Wisconsin-Madison, Madison, WI 53706, USA
Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
* Author to whom correspondence should be addressed.
Received: 1 July 2012; in revised form: 11 August 2012 / Accepted: 21 August 2012 / Published: 27 August 2012
(This article belongs to the Special Issue Autophagy
Abstract: Viruses commandeer regulatory pathways of their hosts to optimize their success as cellular parasites. The human tumor viruses, Epstein-Barr Virus (EBV), Kaposi’s Sarcoma Herpesvirus (KSHV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) all affect autophagy for their own ends. EBV and KSHV regulate it during latent infections, a phase when no progeny virus is produced, while HBV and HCV use autophagy to promote their productive infections. Here we shall compare and contrast how these human tumor viruses regulate autophagy and what they gain by the appropriation of this cellular pathway.
Keywords: Epstein-Barr Virus; Kaposi’s Sarcoma Herpesvirus; Hepatitis B Virus; Hepatitis C Virus; human tumor virus; autophagy; cancer
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Cite This Article
MDPI and ACS Style
Pratt, Z.L.; Sugden, B. How Human Tumor Viruses Make Use of Autophagy. Cells 2012, 1, 617-630.
Pratt ZL, Sugden B. How Human Tumor Viruses Make Use of Autophagy. Cells. 2012; 1(3):617-630.
Pratt, Zachary L.; Sugden, Bill. 2012. "How Human Tumor Viruses Make Use of Autophagy." Cells 1, no. 3: 617-630.