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Cells 2012, 1(3), 631-645; doi:10.3390/cells1030631
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Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis

1,2
 and 1,2,*
1 Department of Mineralized Tissue Biology, Forsyth Institute, 245 First Str., Cambridge, MA 02142, USA 2 Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
* Author to whom correspondence should be addressed.
Received: 24 July 2012 / Revised: 2 August 2012 / Accepted: 20 August 2012 / Published: 30 August 2012
(This article belongs to the Special Issue Cellular Stress Response)
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Abstract

Human enamel development of the permanent teeth takes place during childhood and stresses encountered during this period can have lasting effects on the appearance and structural integrity of the enamel. One of the most common examples of this is the development of dental fluorosis after childhood exposure to excess fluoride, an elemental agent used to increase enamel hardness and prevent dental caries. Currently the molecular mechanism responsible for dental fluorosis remains unknown; however, recent work suggests dental fluorosis may be the result of activated stress response pathways in ameloblasts during the development of permanent teeth. Using fluorosis as an example, the role of stress response pathways during enamel maturation is discussed.
Keywords: enamel; amelogenesis; fluorosis; ameloblast; endoplasmic reticulum stress; unfolded protein response enamel; amelogenesis; fluorosis; ameloblast; endoplasmic reticulum stress; unfolded protein response
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sierant, M.L.; Bartlett, J.D. Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis. Cells 2012, 1, 631-645.

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