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Autophagy and Cancer
AbstractAutophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks to the energetic supply provided by organelle degradation typically driven by autophagy following a stepwise pathway. The main actors of the autophagic machinery as well as the features shared with apoptosis will be described. Special attention will be paid to the effects of autophagy manipulation.
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Aredia, F.; Guamán Ortiz, L.M.; Giansanti, V.; Scovassi, A.I. Autophagy and Cancer. Cells 2012, 1, 520-534.View more citation formats
Aredia F, Guamán Ortiz LM, Giansanti V, Scovassi AI. Autophagy and Cancer. Cells. 2012; 1(3):520-534.Chicago/Turabian Style
Aredia, Francesca; Guamán Ortiz, Luis Miguel; Giansanti, Vincenzo; Scovassi, A. Ivana. 2012. "Autophagy and Cancer." Cells 1, no. 3: 520-534.