Next Article in Journal / Special Issue
Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer
Previous Article in Journal / Special Issue
The Role of Autophagy in Crohn’s Disease
Cells 2012, 1(3), 520-534; doi:10.3390/cells1030520
Review

Autophagy and Cancer

1
,
1,2
,
1
 and
1,*
1 IGM-CNR, Via Abbiategrasso 207, Pavia 27100, Italy 2 UTPL, Loja 1101608, Ecuador
* Author to whom correspondence should be addressed.
Received: 14 June 2012 / Revised: 28 June 2012 / Accepted: 30 July 2012 / Published: 13 August 2012
(This article belongs to the Special Issue Autophagy)
View Full-Text   |   Download PDF [1173 KB, uploaded 13 August 2012]   |   Browse Figures

Abstract

Autophagy is a housekeeping survival mechanism with a protective function against stress conditions. However, when stress severity or duration increases, it may promote cell death. Paradoxically, autophagy favors cancer development, since cancer cells could enhance their proliferation potential (thus becoming able to resist anticancer therapy) thanks to the energetic supply provided by organelle degradation typically driven by autophagy following a stepwise pathway. The main actors of the autophagic machinery as well as the features shared with apoptosis will be described. Special attention will be paid to the effects of autophagy manipulation.
Keywords: apoptosis; autophagy; cancer; cell death apoptosis; autophagy; cancer; cell death
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplement

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Aredia, F.; Guamán Ortiz, L.M.; Giansanti, V.; Scovassi, A.I. Autophagy and Cancer. Cells 2012, 1, 520-534.

View more citation formats

Related Articles

Article Metrics

Comments

Cited By

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert