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Cells 2012, 1(3), 492-519; doi:10.3390/cells1030492
Review

The Role of Autophagy in Crohn’s Disease

1,2,*  and 2,3
Received: 18 June 2012 / Revised: 20 July 2012 / Accepted: 23 July 2012 / Published: 3 August 2012
(This article belongs to the Special Issue Autophagy)
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Abstract

(Macro)-autophagy is a homeostatic process by which eukaryotic cells dispose of protein aggregates and damaged organelles. Autophagy is also used to degrade micro-organisms that invade intracellularly in a process termed xenophagy. Genome-wide association scans have recently identified autophagy genes as conferring susceptibility to Crohn’s disease (CD), one of the chronic inflammatory bowel diseases, with evidence suggesting that CD arises from a defective innate immune response to enteric bacteria. Here we review the emerging role of autophagy in CD, with particular focus on xenophagy and enteric E. coli strains with an adherent and invasive phenotype that have been consistently isolated from CD patients with ileal disease.
Keywords: autophagy; Crohn’s disease; inflammatory bowel disease; ATG16L1; NOD2; IRGM autophagy; Crohn’s disease; inflammatory bowel disease; ATG16L1; NOD2; IRGM
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Henderson, P.; Stevens, C. The Role of Autophagy in Crohn’s Disease. Cells 2012, 1, 492-519.

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