Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Cells 2012, 1(3), 535-557; doi:10.3390/cells1030535
Review

Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer

1,* , 1
, 1
 and 1,2,*
Received: 7 May 2012; in revised form: 4 July 2012 / Accepted: 1 August 2012 / Published: 21 August 2012
(This article belongs to the Special Issue Autophagy)
View Full-Text   |   Download PDF [435 KB, uploaded 21 August 2012]   |   Browse Figure
Abstract: The intestine lies at the interface between the organism and its environment and responds to infection/inflammation in a multi-leveled manner, potentially leading to chronic inflammatory pathologies and cancer formation. Indeed, the immune response at the intestinal epithelium has been found to be involved in the origin and development of colorectal cancer, which is the third most commonly diagnosed neoplastic disease. Among the mechanisms induced upon inflammation, autophagy appears as a defensive strategy for the clearance of invading microbes and intracellular waste components. Autophagy has also been found to play an important role in colorectal cancer, where it seems to have a pro-survival or pro-death function depending on the stage of the neoplastic process. In this paper we discuss the dual role of autophagy in colorectal cancer and review evidence showing that modulation of autophagy affects the immune response and cancer biology. The study of key players involved in autophagy might contribute to the design of new approaches for colorectal cancer, consisting in combined therapies capable of modifying cancer-specific metabolism rather than simply evoking a generic apoptotic and/or autophagic response, thus enhancing the efficacy of currently used drugs and treatments.
Keywords: autophagy; colorectal cancer; inflammation; chemotherapy; p38a autophagy; colorectal cancer; inflammation; chemotherapy; p38a
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Madia, F.; Grossi, V.; Peserico, A.; Simone, C. Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer. Cells 2012, 1, 535-557.

AMA Style

Madia F, Grossi V, Peserico A, Simone C. Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer. Cells. 2012; 1(3):535-557.

Chicago/Turabian Style

Madia, Federica; Grossi, Valentina; Peserico, Alessia; Simone, Cristiano. 2012. "Updates from the Intestinal Front Line: Autophagic Weapons against Inflammation and Cancer." Cells 1, no. 3: 535-557.



Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert