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Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, O/N-1, bus 802, Herestraat 49, Leuven, BE-3000, Belgium
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Received: 14 May 2012; in revised form: 6 June 2012 / Accepted: 15 June 2012 / Published: 6 July 2012
(This article belongs to the Special Issue Autophagy
Abstract: Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-XL and Mcl-1). This binding is regulated by a variety of proteins and compounds that are able to enhance or inhibit the Bcl-2/Beclin 1 interaction in order to repress or activate autophagy, respectively. In this review we will focus on this interaction and discuss its characteristics, relevance and regulation.
Keywords: autophagy; Bcl-2; Bcl-XL; Mcl-1; Beclin 1; JNK1; DAPK; IP3R; Naf-1; BH3 mimetics
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Decuypere, J.-P.; Parys, J.B.; Bultynck, G. Regulation of the Autophagic Bcl-2/Beclin 1 Interaction. Cells 2012, 1, 284-312.
Decuypere J-P, Parys JB, Bultynck G. Regulation of the Autophagic Bcl-2/Beclin 1 Interaction. Cells. 2012; 1(3):284-312.
Decuypere, Jean-Paul; Parys, Jan B.; Bultynck, Geert. 2012. "Regulation of the Autophagic Bcl-2/Beclin 1 Interaction." Cells 1, no. 3: 284-312.