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Cells 2012, 1(3), 248-262; doi:10.3390/cells1030248
Review

The Selectivity and Specificity of Autophagy in Drosophila

1,2,†
Received: 23 May 2012; in revised form: 19 June 2012 / Accepted: 20 June 2012 / Published: 29 June 2012
(This article belongs to the Special Issue Autophagy)
View Full-Text   |   Download PDF [93 KB, uploaded 29 June 2012]
Abstract: Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the initial belief that autophagy is a nonselective bulk process, there is growing evidence during the last years that sequestration and degradation of cellular material by autophagy can be accomplished in a selective and specific manner. Given the role of autophagy and selective autophagy in several disease related processes such as tumorigenesis, neurodegeneration and infections, it is very important to dissect the molecular mechanisms of selective autophagy, in the context of the system and the organism. An excellent genetically tractable model organism to study autophagy is Drosophila, which appears to have a highly conserved autophagic machinery compared with mammals. However, the mechanisms of selective autophagy in Drosophila have been largely unexplored. The aim of this review is to summarize recent discoveries about the selectivity of autophagy in Drosophila.
Keywords: autophagy; development; Drosophila; p62; Ref(2)P; programmed cell death; selective autophagy receptors autophagy; development; Drosophila; p62; Ref(2)P; programmed cell death; selective autophagy receptors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nezis, I.P. The Selectivity and Specificity of Autophagy in Drosophila. Cells 2012, 1, 248-262.

AMA Style

Nezis IP. The Selectivity and Specificity of Autophagy in Drosophila. Cells. 2012; 1(3):248-262.

Chicago/Turabian Style

Nezis, Ioannis P. 2012. "The Selectivity and Specificity of Autophagy in Drosophila." Cells 1, no. 3: 248-262.


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