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Cells 2012, 1(3), 248-262; doi:10.3390/cells1030248

The Selectivity and Specificity of Autophagy in Drosophila

Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0310 Oslo, Norway
Department of Biochemistry, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0310 Oslo, Norway
Current address: School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
Received: 23 May 2012 / Revised: 19 June 2012 / Accepted: 20 June 2012 / Published: 29 June 2012
(This article belongs to the Special Issue Autophagy)
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Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. Despite the initial belief that autophagy is a nonselective bulk process, there is growing evidence during the last years that sequestration and degradation of cellular material by autophagy can be accomplished in a selective and specific manner. Given the role of autophagy and selective autophagy in several disease related processes such as tumorigenesis, neurodegeneration and infections, it is very important to dissect the molecular mechanisms of selective autophagy, in the context of the system and the organism. An excellent genetically tractable model organism to study autophagy is Drosophila, which appears to have a highly conserved autophagic machinery compared with mammals. However, the mechanisms of selective autophagy in Drosophila have been largely unexplored. The aim of this review is to summarize recent discoveries about the selectivity of autophagy in Drosophila.
Keywords: autophagy; development; Drosophila; p62; Ref(2)P; programmed cell death; selective autophagy receptors autophagy; development; Drosophila; p62; Ref(2)P; programmed cell death; selective autophagy receptors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nezis, I.P. The Selectivity and Specificity of Autophagy in Drosophila. Cells 2012, 1, 248-262.

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