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Polymers 2017, 9(6), 210; doi:10.3390/polym9060210

Preparation and Characterization of Quaternized Chitosan Coated Alginate Microspheres for Blue Dextran Delivery

Department of Chemical and Materials Engineering, National Yunlin University of Science and Technology, Yunlin 64002, Taiwan
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Author to whom correspondence should be addressed.
Academic Editors: Chih-Feng Huang, Jinlian Hu and Rui Xiao
Received: 1 May 2017 / Revised: 30 May 2017 / Accepted: 5 June 2017 / Published: 7 June 2017
(This article belongs to the Special Issue Functionally Responsive Polymeric Materials)
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Abstract

In this study, 2-[(Acryloyloxy)ethyl]trimethylammonium chloride was graft polymerized onto chitosan (CS) to form quaternary ammonium CS (QAC) by using ammonium persulfate as a redox initiator. Alginate (ALG) microspheres loaded with a water-soluble macromolecular model drug, blue dextran (BD), were obtained by corporation of coaxial gas-flow method and ionic gelation process. CS and QAC were then coated on the surfaces of ALG microspheres to generate core/shell structured CS/ALG and QAC/ALG microspheres, respectively. The experiment result showed that QAC/ALG microspheres had a smaller particle size due to the stronger electrostatic interactions between QAC and ALG molecules. In vitro drug release studies at pH 7.4 and pH 9.0 exhibited that the release rate of BD was significantly decreased after ALG microspheres coating with CS and QAC. Moreover, ALG microspheres coated with QAC showed a prolonged release profile for BD at pH 9.0. Therefore, QAC/ALG microspheres may be a promising hydrophilic macromolecular drug carrier for a prolonged and sustained delivery. View Full-Text
Keywords: alginate; quaternary ammonium chitosan; graft polymerized; microspheres; drug release alginate; quaternary ammonium chitosan; graft polymerized; microspheres; drug release
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Chen, K.-Y.; Zeng, S.-Y. Preparation and Characterization of Quaternized Chitosan Coated Alginate Microspheres for Blue Dextran Delivery. Polymers 2017, 9, 210.

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