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Polymers 2017, 9(6), 222; doi:10.3390/polym9060222

Reinforcement of Gelatin-Based Nanofilled Polymer Biocomposite by Crystalline Cellulose from Cotton for Advanced Wound Dressing Applications

1
Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Savar, Dhaka 1349, Bangladesh
2
Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
3
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung City 40201, Taiwan
4
Department of Microbiology, Noakhali Science and Technology University, Noakhali 3814, Bangladesh
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Joao F. Mano
Received: 7 April 2017 / Revised: 6 June 2017 / Accepted: 12 June 2017 / Published: 13 June 2017
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Abstract

This study is designed to extract crystalline cellulose from cotton and reinforcing gelatin film for biomedical applications, especially as a wound dressing material for its exceptional biocompatibility and bio-activity. Moreover, gelatin helps in wound healing and crystalline cellulose as additive can improve its properties. Crystalline cellulose was prepared through hydrolysis and the effects of crystalline cellulose loading on the morphology, mechanical properties, and water sensitivity of the nanocomposite were investigated by means of scanning electron microscopy, tensile strength testing, and water absorption testing. Developed biocomposite film showed homogeneous dispersion of crystalline cellulose within the gelatin matrix and strong interfacial adherence between the matrix and reinforcement. Samples were tested for biocompatibility and in vitro cytotoxicity and found to have excellent biocompatibility without having any cytotoxicity. In vivo wound healing study in an animal model showed 40% increased healing than the model dressed by conventional dressing. View Full-Text
Keywords: nanofilled composites; crystalline cellulose; gelatin; wound dressing; biocomposites nanofilled composites; crystalline cellulose; gelatin; wound dressing; biocomposites
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Bhowmik, S.; Islam, J.M.M.; Debnath, T.; Miah, M.Y.; Bhattacharjee, S.; Khan, M.A. Reinforcement of Gelatin-Based Nanofilled Polymer Biocomposite by Crystalline Cellulose from Cotton for Advanced Wound Dressing Applications. Polymers 2017, 9, 222.

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