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Polymers 2017, 9(6), 211; doi:10.3390/polym9060211

DNA Binding with Acetate Bis(1,10-phenanthroline)silver(I) Monohydrate in a Solution and Metallization of Formed Structures

1
Department of Physics, St. Petersburg State University, Universitetskaya Naberezhnaya 3/7, 199037 St. Petersburg, Russia
2
Pro-Brite Company, Sofiyskaya ul., 93, 192289 St. Petersburg, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Helmut Schlaad
Received: 31 March 2017 / Revised: 15 May 2017 / Accepted: 17 May 2017 / Published: 8 June 2017
(This article belongs to the Special Issue Bio-inspired and Bio-based Polymers)
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Abstract

The study of DNA interaction with the acetate bis(1,10-phenanthroline)silver(I) monohydrate in a solution is of interest both for understanding the mechanism of biological activity of silver compound and for forming ordered structures (DNA fibrils) that can be used to solve various problems in the field of nanotechnology. The analysis of changing the DNA conformation (secondary structure, persistent length and volume effects) during the interaction by the methods of UV spectroscopy with the analysis of DNA melting, circular dichroism, viscosity, flow birefringence, AFM (atomic force microscopy) and SEM (scanning electron microscopy) was performed. The formation of two types of complexes was observed. At lower concentration of compound in DNA solution, silver atoms form the coordination bonds with a macromolecule, while the released phenanthroline ligands intercalate between DNA bases. When the concentration of the compound increases, the phenanthroline ligands form an ordered “layer” around the helix. The excess of silver compounds in the DNA solution (with more than five silver atoms per base pair), DNA precipitation is observed with the formation of long fibrils. It was shown that the binding of silver to DNA during the formation of complexes provides further metallization of the resulting structures with the aid of reducing agents; phenanthroline ligands influence the result of such metallization. View Full-Text
Keywords: DNA; bis(1,10-phenanthroline)silver(I) monohydrate; DNA fibrils with silver; silver reduction on DNA DNA; bis(1,10-phenanthroline)silver(I) monohydrate; DNA fibrils with silver; silver reduction on DNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kasyanenko, N.; Qiushi, Z.; Bakulev, V.; Osolodkov, M.; Sokolov, P.; Demidov, V. DNA Binding with Acetate Bis(1,10-phenanthroline)silver(I) Monohydrate in a Solution and Metallization of Formed Structures. Polymers 2017, 9, 211.

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