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Polymers 2017, 9(4), 119; doi:10.3390/polym9040119

Thermo-Responsive Poly(N-Isopropylacrylamide)-Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing

1
Department of Chemical and Materials Engineering, Donadeo Innovation Centre in Engineering, 116 Street and 85 Avenue, Edmonton, AB T6G 2G6, Canada
2
The Petroleum and Petrochemical College, Center of Excellence on Petrochemical and Materials Technology, Chulalongkorn University, Soi Chulalongkorn 12, Pathumwan, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Shiyong Liu
Received: 29 January 2017 / Revised: 16 March 2017 / Accepted: 21 March 2017 / Published: 24 March 2017
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Abstract

Thermo-responsive hydrogels containing poly(N-isopropylacrylamide) (PNIPAAm), reinforced both with covalent and non-covalent interactions with cellulose nanocrystals (CNC), were synthesized via free-radical polymerization in the absence of any additional cross-linkers. The properties of PNIPAAm-CNC hybrid hydrogels were dependent on the amounts of incorporated CNC. The thermal stability of the hydrogels decreased with increasing CNC content. The rheological measurement indicated that the elastic and viscous moduli of hydrogels increased with the higher amounts of CNC addition, representing stronger mechanical properties of the hydrogels. Moreover, the hydrogel injection also supported the hypothesis that CNC reinforced the hydrogels; the increased CNC content exhibited higher structural integrity upon injection. The PNIPAAm-CNC hybrid hydrogels exhibited clear thermo-responsive behavior; the volume phase transition temperature (VPTT) was in the range of 36 to 39 °C, which is close to normal human body temperature. For wound dressing purposes, metronidazole, an antibiotic and antiprotozoal often used for skin infections, was used as a target drug to study drug-loading and the release properties of the hydrogels. The hydrogels showed a good drug-loading capacity at room temperature and a burst drug release, which was followed by slow and sustained release at 37 °C. These results suggested that newly developed drugs containing injectable hydrogels are promising materials for wound dressing. View Full-Text
Keywords: poly(N-isopropylacrylamide); cellulose nanocrystals; hybrid hydrogels; thermal responsive; wound dressing poly(N-isopropylacrylamide); cellulose nanocrystals; hybrid hydrogels; thermal responsive; wound dressing
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MDPI and ACS Style

Zubik, K.; Singhsa, P.; Wang, Y.; Manuspiya, H.; Narain, R. Thermo-Responsive Poly(N-Isopropylacrylamide)-Cellulose Nanocrystals Hybrid Hydrogels for Wound Dressing. Polymers 2017, 9, 119.

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