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Polymers 2017, 9(4), 123; doi:10.3390/polym9040123

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

1
Department of Physical Chemistry of Polymers, “Petru Poni” Institute of Macromolecular Chemistry of the Romanian Academy, Iași 700487, Romania
2
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Izmir 35100, Turkey
3
Department of Analytical Chemistry, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi 700115, Romania
4
Department of Pathophysiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi 700115, Romania
5
Department of Histology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 Universităţii Street, Iaşi 700115, Romania
6
Department of Pharmacology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi 700115, Romania
*
Authors to whom correspondence should be addressed.
Academic Editor: Patrick van Rijn
Received: 4 March 2017 / Revised: 20 March 2017 / Accepted: 22 March 2017 / Published: 27 March 2017
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Abstract

Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical–chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by “in vivo” tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2–7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease. View Full-Text
Keywords: methotrexate; cryogel; acute toxicity; biocompatibility; release; pH responsiveness methotrexate; cryogel; acute toxicity; biocompatibility; release; pH responsiveness
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Cheaburu Yilmaz, C.N.; Pamfil, D.; Vasile, C.; Bibire, N.; Lupuşoru, R.-V.; Zamfir, C.-L.; Lupușoru, C.E. Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy. Polymers 2017, 9, 123.

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