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Polymers 2016, 8(4), 161; doi:10.3390/polym8040161

Biodegradable Polyphosphazene Based Peptide-Polymer Hybrids

1
Institute of Polymer Chemistry, Johannes Kepler University Linz (JKU), Altenberger Straße 69, A-4040 Linz, Austria
2
Institute of Organic Chemistry, Johannes Kepler University Linz (JKU), Altenberger Straße 69, A-4040 Linz, Austria
3
Institute for Bioscience and Biotechnology Research, University of Maryland, 9600 Gudelsky Drive, Rockville, MD 20850, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Takashi Tsujimoto
Received: 11 March 2016 / Revised: 13 April 2016 / Accepted: 18 April 2016 / Published: 22 April 2016
(This article belongs to the Special Issue Biodegradable Polymers)
View Full-Text   |   Download PDF [2588 KB, uploaded 22 April 2016]   |  

Abstract

A novel series of peptide based hybrid polymers designed to undergo enzymatic degradation is presented, via macrosubstitution of a polyphosphazene backbone with the tetrapeptide Gly-Phe-Leu-Gly. Further co-substitution of the hybrid polymers with hydrophilic polyalkylene oxide Jeffamine M-1000 leads to water soluble and biodegradable hybrid polymers. Detailed degradation studies, via 31P NMR spectroscopy, dynamic light scattering and field flow fractionation show the polymers degrade via a combination of enzymatic, as well as hydrolytic pathways. The peptide sequence was chosen due to its known property to undergo lysosomal degradation; hence, these degradable, water soluble polymers could be of significant interest for the use as polymer therapeutics. In this context, we investigated conjugation of the immune response modifier imiquimod to the polymers via the tetrapeptide and report the self-assembly behavior of the conjugate, as well as its enzymatically triggered drug release behavior. View Full-Text
Keywords: Peptide-polymer hybrid; biodegradable polymer; peptide-polymer conjugate; polyphosphazene; polymer therapeutics; hydrolytic degradation; enzymatic degradation; imiquimod (R837) Peptide-polymer hybrid; biodegradable polymer; peptide-polymer conjugate; polyphosphazene; polymer therapeutics; hydrolytic degradation; enzymatic degradation; imiquimod (R837)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Linhardt, A.; König, M.; Schöfberger, W.; Brüggemann, O.; Andrianov, A.K.; Teasdale, I. Biodegradable Polyphosphazene Based Peptide-Polymer Hybrids. Polymers 2016, 8, 161.

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