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Polymers 2015, 7(10), 2061-2077; doi:10.3390/polym7101500

Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs

1
Department of Mechanical Engineering, Korea Polytechnic University, 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
2
Research Institute, T&R Biofab Co. Ltd., 237 Sangidaehak-Ro, Siheung-Si, Gyeonggi-Do 15073, Korea
3
Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, YangSan, Gyeongnam 676-870, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Jianxun Ding
Received: 12 August 2015 / Revised: 30 September 2015 / Accepted: 10 October 2015 / Published: 21 October 2015
(This article belongs to the Special Issue Functional Polymers for Medical Applications)
View Full-Text   |   Download PDF [8113 KB, uploaded 23 October 2015]   |  

Abstract

This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to compare results with those of a non-resorbable titanium mesh membrane. After preparation of PCL/PLGA/β-TCP membranes using extrusion-based 3D printing technology; mechanical tensile testing and in vitro cell proliferation testing were performed. Implant surgery and guided bone regeneration were performed randomly in three groups (a no membrane group, a titanium membrane group, and a PCL/PLGA/β-TCP membrane group (n = 8 per group)). Histological and histometric analyses were conducted to evaluate effects on bone regeneration and osseointegration. Using the results of mechanical testing; a PCL/PLGA/β-TCP ratio of 2:6:2 was selected. The new bone areas (%) in buccal defects around implants were highest in the PCL/PLGA/β-TCP group and significantly higher than in the control group (p < 0.05). Bone-to-implant contact ratios (%) were also significantly higher in the PCL/PLGA/β-TCP and titanium groups than in the control group (p < 0.05). When the guided bone regeneration procedure was performed using the PCL/PLGA/β-TCP membrane; new bone formation around the implant and osseointegration were not inferior to those of the non-resorbable pre-formed titanium mesh membrane. View Full-Text
Keywords: PCL/PLGA/β-TCP; 3D printing; titanium membrane; guided bone regeneration; osseointegration; beagle dog PCL/PLGA/β-TCP; 3D printing; titanium membrane; guided bone regeneration; osseointegration; beagle dog
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shim, J.-H.; Won, J.-Y.; Sung, S.-J.; Lim, D.-H.; Yun, W.-S.; Jeon, Y.-C.; Huh, J.-B. Comparative Efficacies of a 3D-Printed PCL/PLGA/β-TCP Membrane and a Titanium Membrane for Guided Bone Regeneration in Beagle Dogs. Polymers 2015, 7, 2061-2077.

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