Polymers 2014, 6(1), 214-242; doi:10.3390/polym6010214
Article

Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine

1,2,3email, 1,4email, 1email, 1email, 2email, 1email, 1,3,* email and 1,* email
Received: 18 November 2013; in revised form: 13 January 2014 / Accepted: 14 January 2014 / Published: 17 January 2014
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two amphiphilic block copolymers using hydrophobic poly(ε-caprolactone) (PCL) and hydrophilic poly(ethylene glycol) (PEG) were successfully synthesized. One of them is an (A-b-B)4 type star polymer [(PCL-b-PEG)4] and the other one is a Y-shaped PEG–(PCL)2. A star-shaped polymer (PCL-b-PEG)4 was prepared by ring-opening polymerization (ROP) of ε-caprolactone continued by click reaction of (PCL-azide)4 and PEG-alkyne. The synthesis of Y-shaped PEG–(PCL)2 block copolymer was carried out via Diels-Alder click reaction of a furan protected maleimide end-functionalized PEG (PEG-MI) with an anthracene end-functionalized PCL following the ROP of ε-caprolactone. The characterization of micelles is carried out using both materials in aqueous media as drug delivery vehicles, which showed satisfying results and enhanced the cytotoxic effect of the anti-cancer drug vinorelbine (VLB). However, micelles consisted of Y-shaped unimers were found to be more convenient for delivery of hydrophobic drugs such as VLB because they formed in lower concentration, carrying a higher amount of drugs and owing a monomodal distribution. We concluded that the free tails of hydrophobic chains in Y-shaped block copolymer facilitate the assembly of amphiphilic material in water to form micelles.
Keywords: polymeric drug delivery systems; micelle; nano formulation; targeted cancer therapy; vinorelbine; amphiphilic block copolymer; star-shaped polymer; Y-shaped polymer
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MDPI and ACS Style

Bahadori, F.; Dag, A.; Durmaz, H.; Cakir, N.; Onyuksel, H.; Tunca, U.; Topcu, G.; Hizal, G. Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine. Polymers 2014, 6, 214-242.

AMA Style

Bahadori F, Dag A, Durmaz H, Cakir N, Onyuksel H, Tunca U, Topcu G, Hizal G. Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine. Polymers. 2014; 6(1):214-242.

Chicago/Turabian Style

Bahadori, Fatemeh; Dag, Aydan; Durmaz, Hakan; Cakir, Nese; Onyuksel, Hayat; Tunca, Umit; Topcu, Gulacti; Hizal, Gurkan. 2014. "Synthesis and Characterization of Biodegradable Amphiphilic Star and Y-Shaped Block Copolymers as Potential Carriers for Vinorelbine." Polymers 6, no. 1: 214-242.

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