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Polymers 2018, 10(1), 21; https://doi.org/10.3390/polym10010021

Antibacterial Films Made of Ionic Complexes of Poly(γ-glutamic acid) and Ethyl Lauroyl Arginate

1
Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, ETSEIB, Diagonal 647, 08028 Barcelona, Spain
2
Health and Environmental Microbiology Lab & UNESCO Chair on Sustainability, Universitat Politècnica de Catalunya, ESEIAAT, Edifici Gaia, Pg. Ernest Lluch/Rambla Sant Nebridi, 08222 Terrassa, Spain
*
Author to whom correspondence should be addressed.
Received: 23 November 2017 / Revised: 15 December 2017 / Accepted: 20 December 2017 / Published: 24 December 2017
(This article belongs to the Special Issue Host-Guest Polymer Complexes)
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Abstract

The biocide agent LAE (ethyl αN-lauroyl l-arginate chloride) was coupled with poly(γ-glutamic acid) (PGGA) to form stable ionic complexes with LAE:PGGA ratios of 1 and 0.5. The nanostructure adopted by these complexes and its response to thermal changes were examined in detail by Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) using synchrotron radiation in real time. A layered biphasic structure with LAE filling the space between the polypeptidic sheets was adopted in these complexes. The complexes were stable up to above 250 °C, non-water soluble, and were able to form consistent transparent films. The release of LAE from the complexes upon incubation in aqueous buffer was examined and found to depend on both pH and complex composition. The antibacterial activity of films made of these complexes against Gram-positive (L. monocytogenes and S. aureus) and Gram-negative (E. coli and S. enterica) bacteria was preliminary evaluated and was found to be very high against the formers and only moderate against the later. The bactericide activity displayed by the LAE·PGGA complexes was directly related with the amount of LAE that was released from the film to the environment. View Full-Text
Keywords: ionic polyglutamic acid complexes; biocide polyglutamic acid; comb-like polyglutamic acid complexes; ethyl lauroyl arginate; antibacterial polymer complexes ionic polyglutamic acid complexes; biocide polyglutamic acid; comb-like polyglutamic acid complexes; ethyl lauroyl arginate; antibacterial polymer complexes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gamarra-Montes, A.; Missagia, B.; Morató, J.; Muñoz-Guerra, S. Antibacterial Films Made of Ionic Complexes of Poly(γ-glutamic acid) and Ethyl Lauroyl Arginate. Polymers 2018, 10, 21.

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