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Polymers 2018, 10(1), 45; https://doi.org/10.3390/polym10010045

Effect of Dendrigraft Generation on the Interaction between Anionic Polyelectrolytes and Dendrigraft Poly(l-Lysine)

IBMM, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France
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Received: 23 November 2017 / Revised: 18 December 2017 / Accepted: 28 December 2017 / Published: 4 January 2018
(This article belongs to the Special Issue Host-Guest Polymer Complexes)
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Abstract

In this present work, three generations of dendrigraft poly(l-Lysine) (DGL) were studied regarding their ability to interact with linear poly (acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonate) (PAMAMPS) of different chemical charge densities (30% and 100%). Frontal analysis continuous capillary electrophoresis (FACCE) was successfully applied to determine binding constants and binding stoichiometries. The effect of DGL generation on the interaction was evaluated for the first three generations (G2, G3, and G4) at different ionic strengths, and the effect of ligand topology (linear PLL vs. dendrigraft DGL) on binding parameters was evaluated. An increase of the biding site constants accompanied with a decrease of the DGL-PAMAMPS (n:1) stoichiometry was observed for increasing DGL generation. The logarithm of the global binding constants decreased linearly with the logarithm of the ionic strength. This double logarithmic representation allowed determining the extent of counter-ions released from the association of DGL molecules onto one PAMAMPS chain that was compared to the total entropic reservoir constituted by the total number of condensed counter-ions before the association. View Full-Text
Keywords: polyelectrolyte complexes; dendrimers; frontal analysis continuous capillary electrophoresis; counter-ion release; binding constants; ionic strength dependence polyelectrolyte complexes; dendrimers; frontal analysis continuous capillary electrophoresis; counter-ion release; binding constants; ionic strength dependence
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lounis, F.M.; Chamieh, J.; Leclercq, L.; Gonzalez, P.; Rossi, J.-C.; Cottet, H. Effect of Dendrigraft Generation on the Interaction between Anionic Polyelectrolytes and Dendrigraft Poly(l-Lysine). Polymers 2018, 10, 45.

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