Next Article in Journal
Enzymatically-Mediated Co-Production of Cellulose Nanocrystals and Fermentable Sugars
Previous Article in Journal
Highly Selective Catalytic Properties of HZSM-5 Zeolite in the Synthesis of Acetyl Triethyl Citrate by the Acetylation of Triethyl Citrate with Acetic Anhydride
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessArticle
Catalysts 2017, 7(11), 320; doi:10.3390/catal7110320

Synthesis of Isoquinolinones via Regioselective Palladium-Catalyzed C–H Activation/Annulation

Department of Chemistry, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China
*
Author to whom correspondence should be addressed.
Received: 11 October 2017 / Revised: 27 October 2017 / Accepted: 27 October 2017 / Published: 30 October 2017
View Full-Text   |   Download PDF [1081 KB, uploaded 30 October 2017]   |  

Abstract

The isoquinoline motif and its derivatives are of significant interest due to their important biological activities. The effective synthesis of substituted isoquinoline compounds has historically been a significant challenge. A new palladium-catalyzed C–H activation/annulation of N-methoxy benzamides and 2,3-allenoic acid esters is described. For the first time, 2,3-allenoic acid esters are employed for the syntheses of 3,4-substituted hydroisoquinolones, the heteroannulation of allenes proceeded smoothly and afforded the products with good yields and excellent regioselectivity. View Full-Text
Keywords: transition-metal catalyst; C–H activation; C–H functionalization; 2,3-allenoic acid esters; hydroisoquinolinones; palladium-catalyzed annulation transition-metal catalyst; C–H activation; C–H functionalization; 2,3-allenoic acid esters; hydroisoquinolinones; palladium-catalyzed annulation
Figures

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Qi, W.; Wu, Y.; Han, Y.; Li, Y. Synthesis of Isoquinolinones via Regioselective Palladium-Catalyzed C–H Activation/Annulation. Catalysts 2017, 7, 320.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Catalysts EISSN 2073-4344 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top