Catalysts 2014, 4(2), 186-195; doi:10.3390/catal4020186

Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane

1email, 1email and 2,* email
Received: 14 February 2014; in revised form: 16 May 2014 / Accepted: 23 May 2014 / Published: 18 June 2014
(This article belongs to the Special Issue Enzymes in Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The baker’s yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (≤25%) and diastereocontrol.
Keywords: baker’s yeast (Saccharomyces cerevisiae); biocatalysis; asymmetric reduction; chiral alcohol; sulfolane
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MDPI and ACS Style

Deasy, R.E.; O'Riordan, N.; Maguire, A.R. Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane. Catalysts 2014, 4, 186-195.

AMA Style

Deasy RE, O'Riordan N, Maguire AR. Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane. Catalysts. 2014; 4(2):186-195.

Chicago/Turabian Style

Deasy, Rebecca E.; O'Riordan, Noreen; Maguire, Anita R. 2014. "Baker’s Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane." Catalysts 4, no. 2: 186-195.

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