Special Issue "Enzymes in Organic Synthesis"
A special issue of Catalysts (ISSN 2073-4344).
Deadline for manuscript submissions: closed (15 February 2014)
The art of organic synthesis rests entirely on the ability to effect transformations between compounds in a selective and effective manner with regio- and sterocontrol, in addition to chemoselectivity. Over the past two decades development of methods for asymmetric synthesis has been a major focus mainly due to the need to access and synthesise compounds destined for pharmaceutical application in enantiopure form. Use of enzymes in organic synthesis is a particularly powerful approach to effect transformations in a highly selective manner usually under mild reaction conditions. The key advantages include the excellent enantiocontrol which can be achieved in enzyme mediated transformations in addition to chemoselectivity which cannot be achieved through traditional organic reactions. Use of enzymes aligns very much with the Green Chemistry approach. Use of enzymes in organic solvents in addition to the traditional aqueous media has significant potential in organic synthesis; in addition designer enzymes complement and enhance the application of wild type enzymes providing broader substrate scope and enhanced selectivity.
Prof. Dr. Anita Maguire
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- asymmetric Synthesis
- green Chemistry