Next Article in Journal
Seed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment
Next Article in Special Issue
Secondary Intracranial Tumors Following Radiotherapy for Pituitary Adenomas: A Systematic Review
Previous Article in Journal
Regional Delivery of Chimeric Antigen Receptor (CAR) T-Cells for Cancer Therapy
Previous Article in Special Issue
The Role of Radiation Induced Injury on Lung Cancer
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Cancers 2017, 9(7), 91;

Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

DNA Damage Laboratory, Physics Department, School of Applied Mathematical and Physical Sciences, National Technical University of Athens, Zografou Campus, 15780 Athens, Greece
Department of Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA
Mayo Medical Scientist Training Program, Mayo Medical School and Mayo Graduate School, Mayo Clinic, Rochester, MN 55905, USA
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA
First Department of Pediatrics, “Aghia Sophia” Children’s Hospital, Medical School, University of Athens, 11527 Athens, Greece
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 26 May 2017 / Revised: 6 July 2017 / Accepted: 14 July 2017 / Published: 18 July 2017
(This article belongs to the Special Issue Radiation-Induced Carcinogenesis)
View Full-Text   |   Download PDF [1537 KB, uploaded 24 July 2017]   |  


Cellular effects of ionizing radiation (IR) are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs), single strand breaks (SSBs) and base lesions within a short DNA region of up to 15–20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1) repair resistant, increasing genomic instability (GI) and malignant transformation and (2) can be considered as persistent “danger” signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity). Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair. View Full-Text
Keywords: ionizing radiation effects; DNA damage and repair; complex DNA damage; carcinogenesis; immune response; radiation therapy ionizing radiation effects; DNA damage and repair; complex DNA damage; carcinogenesis; immune response; radiation therapy

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Mavragani, I.V.; Nikitaki, Z.; Souli, M.P.; Aziz, A.; Nowsheen, S.; Aziz, K.; Rogakou, E.; Georgakilas, A.G. Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis. Cancers 2017, 9, 91.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top