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Cancers 2017, 9(7), 93; doi:10.3390/cancers9070093

Seed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment

1
Department of Medical Laboratory Sciences, University of Delaware, Room 305, Willard Hall Education Building, 16 West Main Street, Newark, DE 19716, USA
2
Department of Biochemistry and Molecular Biology, Molecular Medicine Graduate Program, University of Maryland School of Medicine and Comprehensive Cancer Center, 108 N. Greene Street, Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 29 June 2017 / Revised: 18 July 2017 / Accepted: 18 July 2017 / Published: 21 July 2017
(This article belongs to the Special Issue Cancer-Associated Fibroblasts)
View Full-Text   |   Download PDF [478 KB, uploaded 25 July 2017]   |  

Abstract

Pancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquely associated with desmoplastic stroma that accounts for 80% of tumor mass. Understanding the biology of stroma can aid the discovery of innovative strategies for eradicating this lethal cancer in the future. This review highlights the critical components in the stroma and how they interact with the cancer cells to convey the devastating tumor progression. View Full-Text
Keywords: pancreatic ductal adenocarcinoma; tumor microenvironment; carcinoma-associated fibroblasts; signaling pathways; immune-suppression and microRNAs pancreatic ductal adenocarcinoma; tumor microenvironment; carcinoma-associated fibroblasts; signaling pathways; immune-suppression and microRNAs
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Lin, H.-J.; Lin, J. Seed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment. Cancers 2017, 9, 93.

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