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Cancers 2017, 9(5), 48; doi:10.3390/cancers9050048

Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview

1
Weill Cornell Medicine in Qatar, Qatar Foundation-Education City, POB 24144 Doha, Qatar
2
Institute of Neuropathology, Heinrich-Heine University Düsseldorf, Moorenstraße 5, 40225 Düsseldorf, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 15 February 2017 / Revised: 2 May 2017 / Accepted: 3 May 2017 / Published: 9 May 2017
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Abstract

Cancer is a main public health problem all over the world. It affects millions of humans no matter their age, gender, education, or social status. Although chemotherapy is the main strategy for the treatment of cancer, a major problem limiting its success is the intrinsic or acquired drug resistance. Therefore, cancer drug resistance is a major impediment in medical oncology resulting in a failure of a successful cancer treatment. This mini-overview focuses on the interdependent relationship between intracellular calcium ([Ca2+]i) signaling and multidrug resistance of cancer cells, acquired upon treatment of tumors with anticancer drugs. We propose that [Ca2+]i signaling modulates gene expression of multidrug resistant (MDR) genes which in turn can be modulated by epigenetic factors which in turn leads to modified protein expression in drug resistant tumor cells. A precise knowledge of these mechanisms will help to develop new therapeutic strategies for drug resistant tumors and will improve current chemotherapy. View Full-Text
Keywords: chemotherapy; drug resistance; calcium signaling; cancer; epigenetic factors chemotherapy; drug resistance; calcium signaling; cancer; epigenetic factors
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Büsselberg, D.; Florea, A.-M. Targeting Intracellular Calcium Signaling ([Ca2+]i) to Overcome Acquired Multidrug Resistance of Cancer Cells: A Mini-Overview. Cancers 2017, 9, 48.

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