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Cancers 2017, 9(5), 50;

Immunotherapy for Colorectal Cancer

Roswell Park Cancer Institute, Department of Medicine, Elm and Carlton St, Buffalo, NY 14263, USA
Mayo Clinic, Division of Medical Oncology, 200 First St. SW, Rochester, MN 55905, USA
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 15 February 2017 / Revised: 5 May 2017 / Accepted: 5 May 2017 / Published: 11 May 2017
(This article belongs to the Special Issue Cancer Immunotherapies)
Full-Text   |   PDF [208 KB, uploaded 11 May 2017]


The recent success of anti-PD1 drugs in metastatic colorectal cancer patients with mismatch repair deficiency generated overwhelming enthusiasm for immunotherapy in the disease. However, patients with mismatch repair deficient colorectal cancer represent only a small subset of the metastatic population. Current research focuses on advancing immunotherapy to earlier stages of the disease including adjuvant and first-line metastatic settings, and on inducing sensitivity to immune checkpoint inhibitor therapy through a combinatorial approach. Here, we review the contemporary understanding of the immune and molecular landscape in colorectal cancer and discuss ongoing clinical trials evaluating novel combination regimens based on immune checkpoint inhibitors. View Full-Text
Keywords: colon cancer; immunotherapy; anti-PD1 colon cancer; immunotherapy; anti-PD1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Boland, P.M.; Ma, W.W. Immunotherapy for Colorectal Cancer. Cancers 2017, 9, 50.

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