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Cancers 2017, 9(5), 44; doi:10.3390/cancers9050044

HGF/Met Signaling in Cancer Invasion: The Impact on Cytoskeleton Remodeling

1
Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China
2
Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China
3
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jill M. Siegfried
Received: 15 March 2017 / Revised: 25 April 2017 / Accepted: 2 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Hepatocyte Growth Factor Pathway in Cancer)
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Abstract

The invasion of cancer cells into surrounding tissue and the vasculature is essential for tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) induces cancer cell migration and invasion. A broad spectrum of mechanisms underlies cancer cell migration and invasion. Cytoskeletal reorganization is of central importance in the development of the phenotype of cancer cells with invasive behavior. Through their roles in cell mechanics, intracellular trafficking, and signaling, cytoskeleton proteins participate in all essential events leading to cell migration. HGF has been involved in cytoskeleton assembly and reorganization, and its role in regulating cytoskeleton dynamics is still expanding. This review summarizes our current understanding of the role of HGF in regulating cytoskeleton remodeling, distribution, and interactions. View Full-Text
Keywords: hepatic growth factor (HGF); cancer; cytoskeleton; metastasis hepatic growth factor (HGF); cancer; cytoskeleton; metastasis
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Xiang, C.; Chen, J.; Fu, P. HGF/Met Signaling in Cancer Invasion: The Impact on Cytoskeleton Remodeling. Cancers 2017, 9, 44.

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