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Cancers 2017, 9(5), 43; doi:10.3390/cancers9050043

Androgen Receptor Could Be a Potential Therapeutic Target in Patients with Advanced Hepatocellular Carcinoma

1
Department of Gastroenterology and Nephrology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan
2
Department of General Surgery, The First Hospital of Hebei Medical University, Donggang Road No. 89, Shijiazhuang 050031, China
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel S. Antonarakis
Received: 27 February 2017 / Revised: 2 May 2017 / Accepted: 3 May 2017 / Published: 5 May 2017
(This article belongs to the Special Issue AR Signaling in Human Malignancies: Prostate Cancer and Beyond)
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Abstract

Hepatocellular carcinoma (HCC) is a male-dominant disease with poor prognosis. Sorafenib is the only approved systemic chemotherapeutic drug for patients with advanced HCC. Previous studies have shown that androgen and androgen receptor (AR) are involved in human hepatocarcinogenesis and the development of HCC. Here, we discuss the recent data on AR and HCC, and the combination of sorafenib and inhibitors of AR for advanced-HCC patients. Androgen-dependent and androgen-independent AR activation exist in human hepatocarcinogenesis. AR could directly control hepatocarcinogenesis and regulate the innate immune system to influence HCC progression. Combination of sorafenib with AR inhibitors might represent a potential treatment for patients with advanced HCC. View Full-Text
Keywords: androgen receptor; hepatocellular carcinoma; sorafenib androgen receptor; hepatocellular carcinoma; sorafenib
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Kanda, T.; Takahashi, K.; Nakamura, M.; Nakamoto, S.; Wu, S.; Haga, Y.; Sasaki, R.; Jiang, X.; Yokosuka, O. Androgen Receptor Could Be a Potential Therapeutic Target in Patients with Advanced Hepatocellular Carcinoma. Cancers 2017, 9, 43.

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