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Cancers 2017, 9(5), 45; doi:10.3390/cancers9050045

Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies

1
Department of Health Sciences, Brock University, St. Catharines, ON L2S 3A1, Canada
2
Centre for Bone and Muscle Health, Brock University, St. Catharines, ON L2S 3A1, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 13 February 2017 / Revised: 2 May 2017 / Accepted: 3 May 2017 / Published: 6 May 2017
View Full-Text   |   Download PDF [254 KB, uploaded 10 May 2017]

Abstract

Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of cancer cells to evade homeostasis and proliferate uncontrollably while avoiding programmed cell death/apoptosis is acquired through mutations to key signaling molecules, which regulate pathways involved in cell proliferation and survival and these mutations allow them to develop resistance to many chemotherapeutic agents, highlighting the need for development of new potent anti-cancer agents. Metformin has long been used as a treatment for type 2 diabetes and has recently attracted attention as a potential agent to be used in the treatment of cancer. The present review summarizes the existing in vitro and in vivo animal studies focusing on the anti-lung cancer effects of metformin and its effects on key proliferative and anti-apoptotic signaling pathways. View Full-Text
Keywords: metformin; lung cancer; cell signaling; proliferation metformin; lung cancer; cell signaling; proliferation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yousef, M.; Tsiani, E. Metformin in Lung Cancer: Review of in Vitro and in Vivo Animal Studies. Cancers 2017, 9, 45.

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