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Cancers 2017, 9(5), 42; doi:10.3390/cancers9050042

KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer

Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland
MAP Kinase Resource, Bioinformatics, Melchiorstrasse 9, 3027 Bern, Switzerland
Proteomics Centre, Institute of Biochemistry, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, Lithuania
Faculty of Mathematics and Informatics, Vilnius University, Naugarduko st. 24, LT-03225 Vilnius, Lithuania
Ministry of Education and Science, A. Volano g. 2, LT-01516 Vilnius, Lithuania
Energy and Biotechnology Engineering Institute, Aleksandro Stulginskio University, Studentų g. 11, LT-53361 Akademija, Lithuania
Division of Human Genome Research Centre, Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekio al. 7, LT-10257 Vilnius, Lithuania
International School of Law and Business, Laisvss pr. 58, LT-05120 Vilnius, Lithuania
Author to whom correspondence should be addressed.
Academic Editor: Samuel C. Mok
Received: 22 March 2017 / Revised: 24 April 2017 / Accepted: 25 April 2017 / Published: 28 April 2017
(This article belongs to the Special Issue Small GTPases in Cancer)
View Full-Text   |   Download PDF [452 KB, uploaded 28 April 2017]   |  


Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths in developed countries. The major treatment of pancreatic cancer is surgery; however, only 15–20% of patients are candidates for it at the diagnosis of disease. On the other hand, survival in patients, who undergo surgery, is less than 30%. In most cancers, genome stability is disturbed and pancreatic cancer is not the exception. Approximately 97% of pancreatic cancers have gene derangements, defined by point mutations, amplifications, deletions, translocations, and inversions. This review describes the most frequent genetic alterations found in pancreatic cancer. View Full-Text
Keywords: KRAS; TP53; CDKN2A; SMAD4; BRCA1; BRCA2; mutation; pancreatic cancer; genetic variant KRAS; TP53; CDKN2A; SMAD4; BRCA1; BRCA2; mutation; pancreatic cancer; genetic variant

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Cicenas, J.; Kvederaviciute, K.; Meskinyte, I.; Meskinyte-Kausiliene, E.; Skeberdyte, A.; Cicenas, J. KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer. Cancers 2017, 9, 42.

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