The Role of the C-Clamp in Wnt-Related Colorectal Cancers
AbstractT-cell Factor/Lymphoid Enhancer Factor (TCF/LEF) transcription factors are major regulators of Wnt targets, and the products of the TCF7 and TCF7L2 genes have both been implicated in the progression of colorectal cancer in animal models and humans. TCFs recognize specific DNA sequences through their high mobility group (HMG) domains, but invertebrate TCFs and some isoforms of vertebrate TCF7 and TCF7L2 contain a second DNA binding domain known as the C-clamp. This review will cover the basic properties of C-clamps and their importance in Wnt signaling, using data from Drosophila, C. elegans, and mammalian cell culture. The connection between C-clamp containing TCFs and colorectal cancer will also be discussed. View Full-Text
Share & Cite This Article
Ravindranath, A.J.; Cadigan, K.M. The Role of the C-Clamp in Wnt-Related Colorectal Cancers. Cancers 2016, 8, 74.
Ravindranath AJ, Cadigan KM. The Role of the C-Clamp in Wnt-Related Colorectal Cancers. Cancers. 2016; 8(8):74.Chicago/Turabian Style
Ravindranath, Aditi J.; Cadigan, Ken M. 2016. "The Role of the C-Clamp in Wnt-Related Colorectal Cancers." Cancers 8, no. 8: 74.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.