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Cancers 2016, 8(8), 73;

Developmental Drift and the Role of Wnt Signaling in Aging

Yale-NUS College, Singapore 138527, Singapore
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
Department of Biological Sciences, National University of Singapore, Singapore 138615, Singapore
Author to whom correspondence should be addressed.
Academic Editors: Renee van Amerongen and Walter Birchmeier
Received: 20 May 2016 / Revised: 12 July 2016 / Accepted: 25 July 2016 / Published: 2 August 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
View Full-Text   |   Download PDF [812 KB, uploaded 2 August 2016]   |  


Population aging is a public health problem affecting the majority of the developed world. As populations age, the incidence of degenerative diseases increases exponentially, leading to large increases in public spending on healthcare. Here we summarize recent findings on the developmental drift theory of aging, and the links that have been established between aging and the Wnt signaling pathways. We focus on insights derived from model organisms connecting the evolutionary basis of aging and the link to developmental programming. View Full-Text
Keywords: wnt; aging; developmental drift wnt; aging; developmental drift

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gruber, J.; Yee, Z.; Tolwinski, N.S. Developmental Drift and the Role of Wnt Signaling in Aging. Cancers 2016, 8, 73.

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