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S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction
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Cancers 2016, 8(7), 60;

Wnt Signaling in Cancer Stem Cell Biology

Laboratory of Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105AZ, The Netherlands
Author to whom correspondence should be addressed.
Academic Editors: Renée van Amerongen and Walter Birchmeier
Received: 18 April 2016 / Revised: 11 June 2016 / Accepted: 20 June 2016 / Published: 27 June 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
Full-Text   |   PDF [799 KB, uploaded 27 June 2016]   |  


Aberrant regulation of Wnt signaling is a common theme seen across many tumor types. Decades of research have unraveled the epigenetic and genetic alterations that result in elevated Wnt pathway activity. More recently, it has become apparent that Wnt signaling levels identify stem-like tumor cells that are responsible for fueling tumor growth. As therapeutic targeting of these tumor stem cells is an intense area of investigation, a concise understanding on how Wnt activity relates to cancer stem cell traits is needed. This review attempts at summarizing the intricacies between Wnt signaling and cancer stem cell biology with a special emphasis on colorectal cancer. View Full-Text
Keywords: Wnt signaling; cancer; stem cells; cancer stem cells; cancer stem cell niche; Wnt inhibition; targeted therapy Wnt signaling; cancer; stem cells; cancer stem cells; cancer stem cell niche; Wnt inhibition; targeted therapy

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de Sousa e Melo, F.; Vermeulen, L. Wnt Signaling in Cancer Stem Cell Biology. Cancers 2016, 8, 60.

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