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Cancers 2016, 8(7), 62; doi:10.3390/cancers8070062

Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer?

1
CHU de Québec Research Center, 2705 Boulevard Laurier, RC-9800, Québec, QC G1V 4G2, Canada
2
Department of Pediatrics, Université Laval, Québec, QC G1V 0A6, Canada
*
Author to whom correspondence should be addressed.
Academic Editors: Renée van Amerongen and Walter Birchmeier
Received: 17 May 2016 / Revised: 19 June 2016 / Accepted: 23 June 2016 / Published: 28 June 2016
(This article belongs to the Special Issue Wnt Signaling in Cancer)
View Full-Text   |   Download PDF [204 KB, uploaded 28 June 2016]

Abstract

Dickkopf-1 (DKK1) is a secreted Wnt/β-catenin pathway antagonist involved in embryogenesis. It was first described 25 years ago for its function in head induction and limb morphogenesis. Since then, this protein has been widely studied in the context of active Wnt/β-catenin signalling during cellular differentiation and development. Dysregulation of DKK1 has been associated with bone pathologies and has now emerged as a potential biomarker of cancer progression and prognosis for several types of malignancies. Reducing the amount of circulating DKK1 may reveal a simple and efficient strategy to limit or reverse cancer growth. This review will provide an overview of the role of Dickkopf-1 in cancer and explore its potential use as a biomarker and therapeutic target. View Full-Text
Keywords: Dickkopf-1; DKK1; Wnt/β-catenin signaling; biomarker; cancer therapeutics; tumour vaccine Dickkopf-1; DKK1; Wnt/β-catenin signaling; biomarker; cancer therapeutics; tumour vaccine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mazon, M.; Masi, D.; Carreau, M. Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer? Cancers 2016, 8, 62.

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