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Cancers 2016, 8(10), 88; doi:10.3390/cancers8100088

Photodynamic Therapy in Gynecologic Malignancies: A Review of the Roswell Park Cancer Institute Experience

Department of Surgery, Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
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Author to whom correspondence should be addressed.
Academic Editor: Michael R. Hamblin
Received: 8 August 2016 / Revised: 9 September 2016 / Accepted: 19 September 2016 / Published: 23 September 2016
(This article belongs to the Special Issue Photodynamic Cancer Therapy)
View Full-Text   |   Download PDF [176 KB, uploaded 23 September 2016]

Abstract

Photodynamic therapy (PDT) is a treatment modality used in the management of solid tumor malignancies that employs the use of a photosensitizing agent, a light source and oxygen in order to illicit a direct cytotoxic effect. Its use in gynecologic malignancies is somewhat novel and has been used for palliative and curative intent. At the Roswell Park Cancer Institute, the use of PDT in the management of gynecologic cancers began in the mid 1980s and since that time 35 patients have received PDT as a treatment for recurrent or metastatic cutaneous and vulvar, vaginal, anal, and cervical recurrences. In our experience, 85% patients with metastatic cutaneous lesions had a complete response. Twenty-seven percent of patients with metastatic vaginal, cervical or anal recurrences had a complete response to therapy with a median response time of 28 months. Side effects from the treatment included moderate to severe burning sensation, pain and edema at the treatment site requiring narcotic pain medication for symptom management in patients who underwent treatment to cutaneous lesions as well as lower genital tract recurrences. PDT should be considered an option in patients who are too frail to undergo the standard of care or decline the standard of care in lieu of a less invasive treatment modality. View Full-Text
Keywords: photodynamic therapy; gynecologic malignancy; vulvar; vaginal; cervical; ovarian; endometrial cancer photodynamic therapy; gynecologic malignancy; vulvar; vaginal; cervical; ovarian; endometrial cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mayor, P.C.; Lele, S. Photodynamic Therapy in Gynecologic Malignancies: A Review of the Roswell Park Cancer Institute Experience. Cancers 2016, 8, 88.

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