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Cancers 2016, 8(10), 87; doi:10.3390/cancers8100087

Novel Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma

1
Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA
2
Institute for Personalized Medicine, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
3
Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Vita Golubovskaya
Received: 3 June 2016 / Revised: 16 August 2016 / Accepted: 8 September 2016 / Published: 22 September 2016
(This article belongs to the Special Issue Cancer Immunotherapies)
View Full-Text   |   Download PDF [980 KB, uploaded 22 September 2016]   |  

Abstract

The immune system plays a key role in preventing tumor formation by recognizing and destroying malignant cells. For over a century, researchers have attempted to harness the immune response as a cancer treatment, although this approach has only recently achieved clinical success. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is associated with cigarette smoking, alcohol consumption, betel nut use, and human papillomavirus infection. Unfortunately, worldwide mortality from HNSCC remains high, partially due to limits on therapy secondary to the significant morbidity associated with current treatments. Therefore, immunotherapeutic approaches to HNSCC treatment are attractive for their potential to reduce morbidity while improving survival. However, the application of immunotherapies to this disease has been challenging because HNSCC is profoundly immunosuppressive, resulting in decreased absolute lymphocyte counts, impaired natural killer cell function, reduced antigen-presenting cell function, and a tumor-permissive cytokine profile. Despite these challenges, numerous clinical trials testing the safety and efficacy of immunotherapeutic approaches to HNSCC treatment are currently underway, many of which have produced promising results. This review will summarize immunotherapeutic approaches to HNSCC that are currently undergoing clinical trials. View Full-Text
Keywords: head and neck squamous cell carcinoma; immunotherapy; tumor vaccine; monoclonal antibody; oncolytic viruses; immune checkpoint inhibitors head and neck squamous cell carcinoma; immunotherapy; tumor vaccine; monoclonal antibody; oncolytic viruses; immune checkpoint inhibitors
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MDPI and ACS Style

Bann, D.V.; Deschler, D.G.; Goyal, N. Novel Immunotherapeutic Approaches for Head and Neck Squamous Cell Carcinoma. Cancers 2016, 8, 87.

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