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Cancers 2016, 8(10), 90; doi:10.3390/cancers8100090

Photodynamic Therapy for Non-Melanoma Skin Cancers

Department of Dermatology, University of Minnesota, Minneapolis, MN 55455, USA
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Received: 1 August 2016 / Accepted: 27 September 2016 / Published: 4 October 2016
(This article belongs to the Special Issue Photodynamic Cancer Therapy)
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Abstract

Non‐melanoma skin cancer (NMSC) is traditionally treated with surgical excision. Nonsurgical methods such as cryotherapy and topical chemotherapeutics, amongst other treatments, are other options. Actinic keratosis (AKs) are considered precancerous lesions that eventually may progress to squamous cell carcinoma (SCC). Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also effective for superficial basal cell carcinoma (BCC). Nodular BCC and Bowen’s disease (SCC in situ) have shown acceptable response rates with PDT, although recurrence rates are higher for these two NMSC subtypes. Methylaminolevulinate (MAL) PDT is a more effective treatment option than 5‐aminolevulinic acid (ALA) PDT for nodular BCC. Several studies have shown that PDT results in superior cosmetic outcomes compared to surgical treatment. PDT is overall well‐tolerated, with pain being the most common side effect. View Full-Text
Keywords: photodynamic therapy; non‐melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma photodynamic therapy; non‐melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Cohen, D.K.; Lee, P.K. Photodynamic Therapy for Non-Melanoma Skin Cancers. Cancers 2016, 8, 90.

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