Next Article in Journal
Dynamic Fluctuation of Circulating Tumor Cells during Cancer Progression
Previous Article in Journal
The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations
Previous Article in Special Issue
Head and Neck Sarcomas: A Comprehensive Cancer Center Experience
Cancers 2014, 6(1), 112-127; doi:10.3390/cancers6010112

Proton Radiotherapy for Pediatric Sarcoma

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
* Author to whom correspondence should be addressed.
Received: 20 October 2013 / Revised: 17 December 2013 / Accepted: 18 December 2013 / Published: 14 January 2014
(This article belongs to the Special Issue Soft Tissue and Bone Sarcoma)
View Full-Text   |   Download PDF [659 KB, uploaded 14 January 2014]   |  


Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by eliminating excess dose deposited beyond the target volume, thereby reducing both the dose of radiation delivered to non-target structures as well as the total radiation dose delivered to a patient. Dosimetric studies comparing proton plans to IMRT and 3D conformal radiation have demonstrated the superiority of protons in numerous pediatric malignancies and data on long-term clinical outcomes and toxicity is emerging. In this article, we review the existing clinical and dosimetric data regarding the use of proton beam radiation in malignant bone and soft tissue sarcomas.
Keywords: sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Ladra, M.M.; Yock, T.I. Proton Radiotherapy for Pediatric Sarcoma. Cancers 2014, 6, 112-127.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert