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Proton Radiotherapy for Pediatric Sarcoma
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
* Author to whom correspondence should be addressed.
Received: 20 October 2013; in revised form: 17 December 2013 / Accepted: 18 December 2013 / Published: 14 January 2014
Abstract: Pediatric sarcomas represent a distinct group of pathologies, with approximately 900 new cases per year in the United States alone. Radiotherapy plays an integral role in the local control of these tumors, which often arise adjacent to critical structures and growing organs. The physical properties of proton beam radiotherapy provide a distinct advantage over standard photon radiation by eliminating excess dose deposited beyond the target volume, thereby reducing both the dose of radiation delivered to non-target structures as well as the total radiation dose delivered to a patient. Dosimetric studies comparing proton plans to IMRT and 3D conformal radiation have demonstrated the superiority of protons in numerous pediatric malignancies and data on long-term clinical outcomes and toxicity is emerging. In this article, we review the existing clinical and dosimetric data regarding the use of proton beam radiation in malignant bone and soft tissue sarcomas.
Keywords: sarcoma; pediatrics; protons; ewings; osteosarcoma; rhabdomyosarcoma; chordoma; chondrosarcoma
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MDPI and ACS Style
Ladra, M.M.; Yock, T.I. Proton Radiotherapy for Pediatric Sarcoma. Cancers 2014, 6, 112-127.
Ladra MM, Yock TI. Proton Radiotherapy for Pediatric Sarcoma. Cancers. 2014; 6(1):112-127.
Ladra, Matthew M.; Yock, Torunn I. 2014. "Proton Radiotherapy for Pediatric Sarcoma." Cancers 6, no. 1: 112-127.