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Cancers 2013, 5(1), 48-63; doi:10.3390/cancers5010048
Review

Gastric Cancer: Current Status of Diagnosis and Treatment

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Received: 30 November 2012; in revised form: 8 January 2013 / Accepted: 11 January 2013 / Published: 16 January 2013
(This article belongs to the Special Issue Gastric Cancer)
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Abstract: Gastric cancer is the second leading cause of death from malignant disease worldwide and most frequently discovered in advanced stages. Because curative surgery is regarded as the only option for cure, early detection of resectable gastric cancer is extremely important for good patient outcomes. Therefore, noninvasive diagnostic modalities such as evolutionary endoscopy and positron emission tomography are utilized as screening tools for gastric cancer. To date, early gastric cancer is being treated using minimally invasive methods such as endoscopic treatment and laparoscopic surgery, while in advanced cancer it is necessary to consider multimodality treatment including chemotherapy, radiotherapy, and surgery. Because of the results of large clinical trials, surgery with extended lymphadenectomy could not be recommended as a standard therapy for advanced gastric cancer. Recent clinical trials had shown survival benefits of adjuvant chemotherapy after curative resection compared with surgery alone. In addition, recent advances of molecular targeted agents would play an important role as one of the modalities for advanced gastric cancer. In this review, we summarize the current status of diagnostic technology and treatment for gastric cancer.
Keywords: gastric cancer; surgery; chemotherapy; radiotherapy; molecular targeted therapy gastric cancer; surgery; chemotherapy; radiotherapy; molecular targeted therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Takahashi, T.; Saikawa, Y.; Kitagawa, Y. Gastric Cancer: Current Status of Diagnosis and Treatment. Cancers 2013, 5, 48-63.

AMA Style

Takahashi T, Saikawa Y, Kitagawa Y. Gastric Cancer: Current Status of Diagnosis and Treatment. Cancers. 2013; 5(1):48-63.

Chicago/Turabian Style

Takahashi, Tsunehiro; Saikawa, Yoshiro; Kitagawa, Yuko. 2013. "Gastric Cancer: Current Status of Diagnosis and Treatment." Cancers 5, no. 1: 48-63.



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