Next Article in Journal
Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors
Next Article in Special Issue
Gastric Cancer: Current Status of Diagnosis and Treatment
Previous Article in Journal
A Comment on Qi et al. An Estimation of Radiobiological Parameters for Head-and-Neck Cancer Cells and the Clinical Implications—Authors' Reply
Cancers 2013, 5(1), 15-26; doi:10.3390/cancers5010015

The Critical Impact of HIF-1a on Gastric Cancer Biology

1,2,*  and 3
1 Department of Surgery, Saga University Faculty of Medicine, Saga 849-8501, Japan 2 Department of Surgery, NHO Higashisaga Hospital, Saga 849-0101, Japan 3 Saga University Faculty of Medicine, Saga 849-8501, Japan
* Author to whom correspondence should be addressed.
Received: 26 November 2012 / Revised: 21 December 2012 / Accepted: 5 January 2013 / Published: 10 January 2013
(This article belongs to the Special Issue Gastric Cancer)
View Full-Text   |   Download PDF [809 KB, uploaded 10 January 2013]   |   Browse Figures


Hypoxia inducible factor-1 (HIF-1) monitors the cellular response to the oxygen levels in solid tumors. Under hypoxia conditions, HIF-1a protein is stabilized and forms a heterodimer with the HIF-1β subunit. The HIF-1 complex activates the transcription of numerous target genes in order to adapt the hypoxic environment in human cancer cells. In gastric cancer patients, HIF-1a activation following extended hypoxia strongly correlates with an aggressive tumor phenotype and a poor prognosis. HIF-1a activation has been also reported to occur via hypoxia-independent mechanisms such as PI3K/AKT/mTOR signaling and ROS production. This article argues for the critical roles of HIF-1a in glucose metabolism, carcinogenesis, angiogenesis, invasion, metastasis, cell survival and chemoresistance, focusing on gastric cancer.
Keywords: HIF-1a; hypoxia; gastric cancer HIF-1a; hypoxia; gastric cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Kitajima, Y.; Miyazaki, K. The Critical Impact of HIF-1a on Gastric Cancer Biology. Cancers 2013, 5, 15-26.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Cancers EISSN 2072-6694 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert