Special Issue "System Biology in Cancer Research"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (20 September 2012)
Dr. Bernard Corfe
Department of Oncology, The Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
Systems biology is an emerging interdisciplinary approach to biological research deliberately embracing a suite of divergent approaches. It seeks to incorporate substantive bodies of literature, high throughput (omics)data, mathemetical modelling to generate in silico models with predictive capacity to improve understanding of biology. In essence it is anti-reductionist. Systems biology is being applied to cancer research at a number of levels and from a number of perspectives, network modelling is applied to large datasets to reveal novel markers or targets of disease (1,2) and also from a ground-up perspective in the modelling of pathways previously described purely qualitatively (3). It is perhaps naive to treat a cancer as behaving like the host organism and the application of models of competition in ecosystems and game theory have also been applied to modelling the behaviour of tumours (4,5).
This special edition of Cancers gives an opportunity to describe recent original research in the application of any systems-biology approach in cancer research, the development or application of new platforms or insights, and is open to reviews of the field and benefits of application. If you would like to discuss an idea for a paper before committing please contact the guest editor.
Dr. Bernard Corfe
- systems biology
- network analysis
- pathways analysis
- data integration
Article: Relative Expression of Vitamin D Hydroxylases, CYP27B1 and CYP24A1, and of Cyclooxygenase-2 and Heterogeneity of Human Colorectal Cancer in Relation to Age, Gender, Tumor Location, and Malignancy: Results from Factor and Cluster Analysis
Cancers 2012, 4(3), 763-776; doi:10.3390/cancers4030763
Received: 22 May 2012; in revised form: 6 July 2012 / Accepted: 13 July 2012 / Published: 26 July 2012| Cited by 2 | PDF Full-text (207 KB) | HTML Full-text | XML Full-text
Cancers 2012, 4(4), 1180-1211; doi:10.3390/cancers4041180
Received: 8 October 2012; in revised form: 31 October 2012 / Accepted: 2 November 2012 / Published: 8 November 2012| Cited by 10 | PDF Full-text (1361 KB) | HTML Full-text | XML Full-text
Cancers 2012, 4(4), 1247-1251; doi:10.3390/cancers4041247
Received: 11 September 2012; in revised form: 17 November 2012 / Accepted: 21 November 2012 / Published: 29 November 2012| PDF Full-text (308 KB) | HTML Full-text | XML Full-text
Last update: 25 February 2014