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Cancers 2012, 4(3), 673-700; doi:10.3390/cancers4030673
Article

Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis

1,2
1 Cytopatholgy Division, Tohkai Cytopathology Institute, Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-uzura, Gifu 500-8285, Japan 2 Department of Tumor Pathology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan
Received: 5 April 2012 / Revised: 14 June 2012 / Accepted: 6 July 2012 / Published: 16 July 2012
(This article belongs to the Special Issue Advances in Cancer Chemoprevention)
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Abstract

Inflammation is involved in all stages of carcinogenesis. Inflammatory bowel disease, such as ulcerative colitis and Crohn’s disease is a longstanding inflammatory disease of intestine with increased risk for colorectal cancer (CRC). Several molecular events involved in chronic inflammatory process are reported to contribute to multi-step carcinogenesis of CRC in the inflamed colon. They include over-production of free radicals, reactive oxygen and nitrogen species, up-regulation of inflammatory enzymes in arachidonic acid biosynthesis pathway, up-regulation of certain cytokines, and intestinal immune system dysfunction. In this article, firstly I briefly introduce our experimental animal models where colorectal neoplasms rapidly develop in the inflamed colorectum. Secondary, data on preclinical cancer chemoprevention studies of inflammation-associated colon carcinogenesis by morin, bezafibrate, and valproic acid, using this novel inflammation-related colorectal carcinogenesis model is described.
Keywords: inflammatory bowel disease; colorectal cancer; chemoprevention; animal model; AOM; DSS; morin; bezafibrate; valproic acid inflammatory bowel disease; colorectal cancer; chemoprevention; animal model; AOM; DSS; morin; bezafibrate; valproic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tanaka, T. Preclinical Cancer Chemoprevention Studies Using Animal Model of Inflammation-Associated Colorectal Carcinogenesis. Cancers 2012, 4, 673-700.

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