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Cancers 2011, 3(4), 4269-4280; doi:10.3390/cancers3044269
Review
Actin—Towards a Deeper Understanding of the Relationship Between Tissue Context, Cellular Function and Tumorigenesis
Cell Culture Essentials, Life Technologies, 7335 Executive Way, Frederick, MD 21703, USA
Received: 17 October 2011; in revised form: 26 November 2011 / Accepted: 7 December 2011 / Published: 14 December 2011
(This article belongs to the Special Issue Tumor Cell Genesis and Its Microenvironment: Chicken or the Egg)
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Abstract: It is well-established that the actin cytoskeleton plays an important role in tumor development yet the contribution made by nuclear actin is ill-defined. In a recent study, nuclear actin was identified as a key mediator through which laminin type III (LN1) acts to control epithelial cell growth. In the breast, epithelial tumors are surrounded by an environment which lacks LN1. These findings point to actin as a potential mediator of tumor development. Here our current understanding of the roles of cytoplasmic and nuclear actin in normal and tumor cell growth is reviewed, relating these functions to cell phenotype in a tissue context.
Keywords: extracellular matrix; laminin; nuclear actin; breast cancer; epithelial
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MDPI and ACS Style
Spencer, V.A. Actin—Towards a Deeper Understanding of the Relationship Between Tissue Context, Cellular Function and Tumorigenesis. Cancers 2011, 3, 4269-4280.
AMA StyleSpencer VA. Actin—Towards a Deeper Understanding of the Relationship Between Tissue Context, Cellular Function and Tumorigenesis. Cancers. 2011; 3(4):4269-4280.
Chicago/Turabian StyleSpencer, Virginia A. 2011. "Actin—Towards a Deeper Understanding of the Relationship Between Tissue Context, Cellular Function and Tumorigenesis." Cancers 3, no. 4: 4269-4280.