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Cancers 2011, 3(3), 3676-3686; doi:10.3390/cancers3033676
Review

The Many Faces of Wnt and Pancreatic Ductal Adenocarcinoma Oncogenesis

1,*  and 2,3
Received: 8 August 2011; in revised form: 23 August 2011 / Accepted: 15 September 2011 / Published: 21 September 2011
(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
View Full-Text   |   Download PDF [107 KB, uploaded 21 September 2011]
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains amongst the most lethal human cancers. PDAC is characterized by the tumor mass containing a paucity of malignant cells in association with a large desmoplastic reaction comprised of a variety of stromal components. Sporadic PDAC oncogenesis occurs as a result of the sequential acquisition of genetic aberrations occurring in core genetic pathways. Unfortunately, the average PDAC contains a large number of genetic aberrations that are not uniform between individual cancers. The interplay between the complex genetics and stromal component may represent a significant barrier to the development of effective therapy for this disease and ultimately be an important factor in PDAC lethality. The Wnt pathway has been identified as a one of the common pathways undergoing genetic alterations in PDAC. Wnt is a complex signal transduction pathway utilizing both a b-catenin dependent (canonical) and b-catenin independent (noncanonical) signals to affect a wide array of intracellular events. Wnt signal transduction is an integral component of pancreas organogenesis promoting the expansion and development of the exocrine pancreas. Pancreatic cancer may utilize the Wnt signaling pathway in concert with other signaling pathways such as notch during tumorigenesis. This review will focus on the role of Wnt signal transduction in pancreatic cancer biology.
Keywords: pancreatic ductal adenocarcinoma; Wnt; Frizzled; K-ras; b-catenin; stroma and angiogenesis pancreatic ductal adenocarcinoma; Wnt; Frizzled; K-ras; b-catenin; stroma and angiogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Weekes, C.D.; Winn, R.A. The Many Faces of Wnt and Pancreatic Ductal Adenocarcinoma Oncogenesis. Cancers 2011, 3, 3676-3686.

AMA Style

Weekes CD, Winn RA. The Many Faces of Wnt and Pancreatic Ductal Adenocarcinoma Oncogenesis. Cancers. 2011; 3(3):3676-3686.

Chicago/Turabian Style

Weekes, Colin D.; Winn, Robert A. 2011. "The Many Faces of Wnt and Pancreatic Ductal Adenocarcinoma Oncogenesis." Cancers 3, no. 3: 3676-3686.


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