Special Issue "Cancer Signaling Pathways and Crosstalk"

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A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 April 2011)

Special Issue Editor

Guest Editor
Dr. Don Benjamin
Growth & Development Unit, Rm. 583 Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland
E-Mail: don.benjamin@unibas.ch
Phone: +41 61 267 21 70
Fax: +41 61 267 07 59
Interests: mTOR; cancer metabolism; glycolysis; signal transduction; mRNA stability

Special Issue Information

Dear Colleagues,

Cell signaling pathways regulate cell growth, proliferation and survival. Many common genetic lesions in cancer involve signaling proteins, either as activating mutations (Ras, PI3k, Akt) or loss of function of tumor suppressors (Pten). Hyperactivation of these pathways drives tumorigenesis and supports tumor growth and leads to the establishment of pathway addiction for a particular cancer. As signals are propagated along these pathways by a relay of protein kinases, this allows access to therapeutic intervention by specific kinase inhibitors that has proven to be clinically successful. While development of kinase inhibitors continues to be actively pursued, successful treatment requires correct targeting of specific inhibitors to tumors addicted to a particular pathway. To this end, much remains to be done in identifying biomarkers for pathway addiction, and crosstalk between parallel signaling pathways in identifying patients most likely to respond to specific inhibitors.

Don Benjamin
Guest Editor

Keywords

  • cancer
  • kinase
  • phosphatase
  • signaling
  • pathway
  • receptor
  • crosstalk
  • growth
  • apoptosis

Published Papers (13 papers)

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Displaying article 1-13
p. 3676-3686
by  and
Cancers 2011, 3(3), 3676-3686; doi:10.3390/cancers3033676
Received: 8 August 2011; in revised form: 23 August 2011 / Accepted: 15 September 2011 / Published: 21 September 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 3242-3278
by , , , , ,  and
Cancers 2011, 3(3), 3242-3278; doi:10.3390/cancers3033242
Received: 12 July 2011; in revised form: 1 August 2011 / Accepted: 3 August 2011 / Published: 10 August 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 3029-3054
by , , ,  and
Cancers 2011, 3(3), 3029-3054; doi:10.3390/cancers3033029
Received: 10 May 2011; in revised form: 6 July 2011 / Accepted: 19 July 2011 / Published: 26 July 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 2990-3001
by , ,  and
Cancers 2011, 3(3), 2990-3001; doi:10.3390/cancers3032990
Received: 9 June 2011; in revised form: 18 July 2011 / Accepted: 19 July 2011 / Published: 22 July 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 2827-2843
by  and
Cancers 2011, 3(3), 2827-2843; doi:10.3390/cancers3032827
Received: 27 April 2011; in revised form: 9 June 2011 / Accepted: 17 June 2011 / Published: 27 June 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 2709-2733
by
Cancers 2011, 3(2), 2709-2733; doi:10.3390/cancers3022709
Received: 6 April 2011; in revised form: 2 June 2011 / Accepted: 14 June 2011 / Published: 20 June 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 2478-2500
by , ,  and
Cancers 2011, 3(2), 2478-2500; doi:10.3390/cancers3022478
Received: 6 April 2011; in revised form: 13 May 2011 / Accepted: 16 May 2011 / Published: 24 May 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 2444-2461
by , , , , , , ,  and
Cancers 2011, 3(2), 2444-2461; doi:10.3390/cancers3022444
Received: 20 April 2011; in revised form: 6 May 2011 / Accepted: 12 May 2011 / Published: 18 May 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 2032-2049
by , , , , , , ,  and
Cancers 2011, 3(2), 2032-2049; doi:10.3390/cancers3022032
Received: 25 February 2011; in revised form: 29 March 2011 / Accepted: 7 April 2011 / Published: 18 April 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 1182-1194
by
Cancers 2011, 3(1), 1182-1194; doi:10.3390/cancers3011182
Received: 18 February 2011; in revised form: 2 March 2011 / Accepted: 3 March 2011 / Published: 8 March 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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p. 971-981
by  and
Cancers 2011, 3(1), 971-981; doi:10.3390/cancers3010971
Received: 31 January 2011; in revised form: 14 February 2011 / Accepted: 24 February 2011 / Published: 2 March 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 700-715
by ,  and
Cancers 2011, 3(1), 700-715; doi:10.3390/cancers3010700
Received: 4 January 2011; in revised form: 25 January 2011 / Accepted: 10 February 2011 / Published: 18 February 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
p. 662-674
by  and
Cancers 2011, 3(1), 662-674; doi:10.3390/cancers3010662
Received: 29 December 2010; in revised form: 30 January 2011 / Accepted: 9 February 2011 / Published: 14 February 2011
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(This article belongs to the Special Issue Cancer Signaling Pathways and Crosstalk)
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Last update: 25 February 2014

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