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Cancers 2011, 3(3), 2858-2869; doi:10.3390/cancers3032858

Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic?

Sysmex Corporation, Central Research Laboratories, Kobe 651-2271, Japan
Chirurgische Klinik, Klinikum Rechts der Isar der TUM, München 81657, Germany
Author to whom correspondence should be addressed.
Received: 10 May 2011 / Revised: 23 June 2011 / Accepted: 27 June 2011 / Published: 7 July 2011
(This article belongs to the Special Issue Prognostic and Predictive Factors in Colorectal Cancer)
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Cancers of the colon and rectum, which rank among the most frequent human tumors, are currently treated by surgical resection in locally restricted tumor stages. However, disease recurrence and formation of local and distant metastasis frequently occur even in cases with successful curative resection of the primary tumor (R0). Recent technological advances in molecular diagnostic analysis have led to a wealth of knowledge about the changes in gene transcription in all stages of colorectal tumors. Differential gene expression, or transcriptome analysis, has been proposed by many groups to predict disease recurrence, clinical outcome, and also response to therapy, in addition to the well-established clinico-pathological factors. However, the clinical usability of gene expression profiling as a reliable and robust prognostic tool that allows evidence-based clinical decisions is currently under debate. In this review, we will discuss the most recent data on the prognostic significance and potential clinical application of genome wide expression analysis in colorectal cancer. View Full-Text
Keywords: colorectal cancer; transcriptome; metastasis; prognosis; therapy prediction colorectal cancer; transcriptome; metastasis; prognosis; therapy prediction
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Shibayama, M.; Maak, M.; Nitsche, U.; Gotoh, K.; Rosenberg, R.; Janssen, K.-P. Prediction of Metastasis and Recurrence in Colorectal Cancer Based on Gene Expression Analysis: Ready for the Clinic? Cancers 2011, 3, 2858-2869.

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