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Cancers 2011, 3(1), 872-882; doi:10.3390/cancers3010872
Review
Molecular Endoscopic Ultrasound for Diagnosis of Pancreatic Cancer
Barbara Bournet 1,2 
, Adeline Pointreau 2 , Yannick Delpu 2 , Janick Selves 2 , Jerome Torrisani 2 , Louis Buscail 1,2,*
and Pierre Cordelier 2
, Adeline Pointreau 2 , Yannick Delpu 2 , Janick Selves 2 , Jerome Torrisani 2 , Louis Buscail 1,2,*
and Pierre Cordelier 2
1
Department of Gastroenterology, University Hospital Center Rangueil, 1 avenue Jean Poulhès, TSA 50032, 31059 Toulouse Cedex 9, France
2
INSERM U1037, University Hospital Center Rangueil, Toulouse, France
* Author to whom correspondence should be addressed.
Received: 18 January 2011; in revised form: 5 February 2011 / Accepted: 22 February 2011 / Published: 24 February 2011
(This article belongs to the Special Issue Pancreatic Cancer)
Download PDF Full-Text [311 KB, uploaded 24 February 2011 12:34 CET]
Abstract: Endoscopic ultrasound-guided fine needle aspiration-biopsy is a safe and effective technique in diagnosing and staging of pancreatic ductal adenocarcinoma. However its predictive negative value does not exceed 50% to 60%. Unfortunately, the majority of pancreatic cancer patients have a metastatic and/or a locally advanced disease (i.e., not eligible for curative resection) which explains the limited access to pancreatic tissue specimens. Endoscopic ultrasound-guided fine needle aspiration-biopsy is the most widely used approach for cytological and histological material sampling in these situations used in up to two thirds of patients with pancreatic cancer. Based on this unique material, we and others developed strategies to improve the differential diagnosis between carcinoma and inflammatory pancreatic lesions by analysis of KRAS oncogene mutation, microRNA expression and methylation, as well as mRNA expression using both qRT-PCR and Low Density Array Taqman analysis. Indeed, differentiating pancreatic cancer from pseudotumoral chronic pancreatitis remains very difficult in current clinical practice, and endoscopic ultrasound-guided fine needle aspiration-biopsy analysis proved to be very helpful. In this review, we will compile the clinical and molecular advantages of using endoscopic ultrasound-guided fine needle aspiration-biopsy in managing pancreatic cancer.
Keywords: endoscopic ultrasound-guided fine needle aspiration-biopsy; pancreatic ductal adenocarcinoma; KRAS oncogene; microRNA; chronic pancreatitis
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MDPI and ACS Style
Bournet, B.; Pointreau, A.; Delpu, Y.; Selves, J.; Torrisani, J.; Buscail, L.; Cordelier, P. Molecular Endoscopic Ultrasound for Diagnosis of Pancreatic Cancer. Cancers 2011, 3, 872-882.
AMA StyleBournet B, Pointreau A, Delpu Y, Selves J, Torrisani J, Buscail L, Cordelier P. Molecular Endoscopic Ultrasound for Diagnosis of Pancreatic Cancer. Cancers. 2011; 3(1):872-882.
Chicago/Turabian StyleBournet, Barbara; Pointreau, Adeline; Delpu, Yannick; Selves, Janick; Torrisani, Jerome; Buscail, Louis; Cordelier, Pierre. 2011. "Molecular Endoscopic Ultrasound for Diagnosis of Pancreatic Cancer." Cancers 3, no. 1: 872-882.